This series of conferences builds on the initial Vatican Observatory conference and its resulting publication, (1988), and on previous jointly-sponsored conferences and their publications: (1993), (1995); and (1998). A future conference will focus on quantum physics and quantum field theory. In Section One, essays on biblical accounts of human nature (Joel B. Green) and on the role of philosophical theories of human nature in recent theology (Fergus Kerr) are paired with “snapshots” of neuroscientific research (Joseph E. LeDoux, Peter Hagoort, Marc Jeannerod, and Leslie A. Brothers) to set the poles between which the volume’s dialogue proceeds. In Section Two, essays of two types bridge the fields of cognitive neuroscience and philosophy of mind: the first begin with findings in science that raise philosophical issues (Michael A. Arbib, LeDoux, Jeannerod); the second type address current philosophical accounts of human nature, focusing especially on reductionism (William R. Stoeger, Nancey Murphy, Theo C. Meyering). Essays in Section Three proceed from neuroscientific or philosophical accounts of human nature to theological interpretations: three essays provide comprehensive accounts of human nature consistent with both theology and science (Philip Clayton, Arthur Peacocke, Ian G. Barbour); others relate findings and general trends in neuroscience to phenomenological and Thomistic accounts of human experience (Stephen Happel), to Christian teaching on life after death (Ted Peters), and to religious experience (Fraser Watts, Wesley J. Wildman, and Leslie Brothers). Section Four offers conflicting answers to the question whether or not a theistic account is needed to make sense of the various dimensions of human nature canvassed in this volume.