This book gathers twenty-two papers presented at the second NLAGA-BIRS Symposium, which was held at Cap Skirring and at the Assane Seck University in Ziguinchor, Senegal, on January 25–30, 2022. The five-day symposium brought together African experts on nonlinear analysis and geometry and their applications, as well as their international partners, to present and discuss mathematical results in various areas. The main goal of the NLAGA project is to advance and consolidate the development of these mathematical fields in West and Central Africa with a focus on solving real-world problems such as coastal erosion, pollution, and urban network and population dynamics problems. The book addresses a range of topics related to partial differential equations, geometric analysis, geometric structures, dynamics, optimization, inverse problems, complex analysis, algebra, algebraic geometry, control theory, shastic approximations, and modelling.