The book provides an extensive overview of semantic technologies and their potential to integrate with existing industrial standards, planning, and execution systems to provide efficient data processing and analysis. It also investigates the design of Industry 5.0 solutions and the need for problem-specific descriptions of production processes, operator skills and states, and sensor monitoring in intelligent spaces. The book is divided into two parts: modelingand optimization. The semantic modeling part provides an overview of ontologies and knowledge graphs that can be used to create Industry 4.0 and 5.0 applications, with two detailed applications presented on a reproducible industrial case study. The optimization part of the book focuses on network science-based process optimization and presents various detailed applications, such as graph-based analytics, assembly line balancing, and community detection.