President Sean Owen Doyle riding on the highest popularity rating since President Kennedy is plunged into the worst possible crisis ever confronted by him or any of his predecessors. A strange flu like virus appears across the nation attacking the same age group that was victimized in the Pandemic of 1918. This time, it is the weapon of choice by a terrorist organization. The disease spreads worldwide and the race is on to develop a vaccine before millions of people die. As panic reigns in the streets of the homeland, President Doyle is confronted with numerous terrorist attacks while the Center for Disease Control is in a race against time to save as many lives as possible from the Pandemic.