This issue of Surgical Clinics of North America focuses on Surgical Patient Safety and is edited by Dr. Feibi Zheng. Articles will include: Human factors approach to surgical patient safety; Teamwork and surgical team based training; Effective handoffs and transfers in surgical patient safety; Effective implementation and utilization of checklists in surgical patient safety; Standardized care pathways as a means to improve patient safety; Evolution of risk calculators and the dawn of artificial intelligence in predicting patient complications; Remote monitoring technology/use of telemedicine to detect and address surgical complications; Rescue after surgical complications; The economics of surgical patient safety; The trainee’s role in patient safety/training residents and medical students in surgical patient safety; The second victim: building surgeon resiliency after complications; Processes to create a culture of surgical patient safety; Provision of defect free care: implementation science in surgical patient safety; Administrative and registry databases for patient safety tracking and quality improvement; and more!