addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides.•    Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives•    Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling•    Features a variety of chromatographic case studies not readily accessible to the general public•    Represents an essential reference resource for academic, industrial, and pharmaceutical researchers