The first edition of led readers through a step-by-step description of a quality improvement intervention as it might unfold in a model hospital, pinpointing the likely obstacles and offering practical strategies for how to overcome them. This newly updated edition draws on fresh examples and modern clinical tools, with new or expanded topics spanning antimicrobial resistance and antimicrobial stewardship, RAND/UCLA appropriateness criteria for using devices, and tiered approaches to CAUTI, CLABSI, and CDI. Unlike other approaches, which focus on the technical aspects of healthcare-associated infections, this book offers a user-friendly manual for effecting real, practical change. Whether resistance comes from physicians who distrust change, nurses who want to protect their turf, or infection preventionists who are removed from the day-to-day work on wards, offers an innovative and accessible approach that focuses on navigating the human element in a hospital quality improvement initiative.