Long regarded as “the book” in the field for in-depth learning as well as decision support at the point of care, continues its tradition as a comprehensive, evidence-based, action-oriented information resource. Presented in companion electronic format updated quarterly, its problem-based orientation spans the full spectrum of problems encountered in adult primary care practice. Chapters address screening, diagnosis, prevention and management, including indications for referral and approaches to patient education and shared decision making. Clear, practical, bulleted recommendations and an extensive annotated bibliography of best references follow detailed discussions of pathophysiology, clinical presentation, differential diagnosis, and strategies for workup and treatment.   Now with its 40th-anniversary edition, this exceptional text is a must-have resource for physicians, nurse practitioners, physician assistants, students, and residents- offering the most complete and up-to-date resource available for primary care education and practice.