explores empirically supported psychosocial interventions in light of our current understanding of the genome. It considers how interventions may be modified and enhanced as the products of genomic research continue to expand – and why they offer the most promise for making substantial gains in treatment and prevention. Providing a clear, accessible assessment of our current knowledge, both of the genome and evidence based treatments, provides practical advice to clinicians,policy makers, and others invested in treating young people who present with a variety of conditions including anxiety, depression, ADHD, autism, substance abuse, and dyslexia. Rende discusses the current understanding of genetic etiology of psychopathology, and explores the support, or lack thereof, for various modes of treatment in light of new genomic knowledge. The overall premise is that our advances in genetics will be put to best therapeutic use by fueling translational psychosocial interventions. Key points raised include: