The work is divided into three parts that focus on the new role of public health departments, emerging challenges and opportunities following the enactment of the Patient Protection and Affordable Care Act (ACA), and recent trends in innovation and investment. Each chapter is practice-oriented to provide insight into the changing landscape of public health while offering practical tips based on the experiences and expertise of leading practitioners. Topics include cross-sector partnership-building, innovations in investment strategies, public health operations, performance management, advances in big data tracking, and more that address the social determinants of health and improve population health. Cases draw on a wide range of perspectives and regions, encouraging the reader, whether a professional or student, to apply the lessons learned to one’s local context.