The handbook aims to bridge the three main OR/MS research domains in sustainability: “Systems Design, Innovation, and Technology,” “Manufacturing, Logistics, and Transportation,” and “Sustainable Natural Resource Management.” Traditionally, these domains are treated separately in the OR/MS literature. By combining the three domains, the handbook will provide a more holistic treatment of MS/OR methodologies to address critical sustainability issues faced by today’s society. Unlike most existing handbooks which only focus on current OR/MS research in sustainability within a domain, this handbook will include a concluding chapter in each of the three parts to discuss and identify potential future research directions in each of the three main domains.