The sciatic nerve is the longest nerve in your body. It runs from the back of your pelvis, through your buttocks, and all the way down both legs, ending at your feet. Signs and symptoms When the sciatic nerve is compressed or irritated, it can cause pain, numbness and a tingling sensation that radiates from your lower back and travels down one of your legs to your foot and toes. The pain can range from being mild to very painful, and may be made worse by sneezing, coughing, or sitting for a long period of time. Some people with sciatica may also experience muscle weakness in the affected leg. While people with sciatica can also have general back pain, the pain associated with sciatica usually affects the buttocks and legs much more than the back. Take action and learn the specific you can start doing today to bring back the joy of pain-free life and get your back in better shape for the future.