London. December 1888. The notorious and as-yet undiscovered genius, Vincent van Gogh, presents Sherlock Holmes with a most unusual case. Aided by his partner Dr. Watson and his paramour Irene Adler, the trio embark on a rousing adventure and find themselves confronting the evil daughter of Professor Moriarty. Aided by Oscar Wilde, the world's greatest detective attempts to solve one of the most audacious crimes of the Victorian era and uncover a Post-Impressionist conspiracy.