This book constitutes the refereed proceedings of the 4th International Conference on Smart Applications and Data Analysis, SADASC 2022, held in Marrakesh, Morocco, during September 22–24, 2022. The 24 full papers and 11 short papers included in this book were carefully reviewed and selected from 64 submissions. They were organized in topical sections as follows: AI-Driven Methods 1; Networking technologies & IoT; AI-Driven Methods 2; Green Energy, Computing and Technologies 1; AI-Driven Methods 3; Green Energy, Computing and Technologies 2; Case studies and Cyber-Physical Systems 1; Case studies and Cyber-Physical Systems 2; and Case studies and Cyber-Physical Systems 3.