This book focuses on three grand challenges that matter for any territory, no matter where it is located: (i) smart growth, a path that more and more cities, regions and countries are adopting having realised the unlimited potential of growth that is based on knowledge, innovation and digital technologies; (ii) safety and security, which is a pre-requisite for quality of life in a world of intense social, natural and technological threats; and (iii) sustainability, use of renewable energy, protection of living ecosystems, addressing climate change and global warming in a period of rapid urbanisation that makes established sustainability models and planning patterns quickly obsolete. The core argument of the book is that problem-solving and novel solutions to these grand challenges emerge in smart ecosystems through connected intelligence. It is the broadest form of intelligence that combines capabilities from heterogeneous actors (humans, organisations, machines) and propel problem-solving through externalities and resource agglomeration, user engagement and collaboration, awareness and behaviour change. This book will be of interest to students and researchers of urban and regional studies, innovation studies, economic geography and urban planning, as well as urban policy makers.