Julian and Missouri Belle have cut a swath of mischief across the United States from New York City to the Louisiana Territories. A successful brother and sister team, it is whispered that they run one of the most inventive and infamous traveling medicine shows in the country. They manage to make a living one step outside the law and two steps ahead of it. The crowds gather whenever their wagon rolls around. In the budding town of Sulfur Creek, Wyoming, it's a well-known fact that young Doctor Eli Mason and his childhood sweetheart, Josephine, will marry one day. With their feet firmly planted on the ground their success together is assured. But when their paths cross, a complicated concoction of practical medicine, magic and Cupid may prove that snake oil is the perfect cure for what ails you.