At a time when global health has been pushed to adopt increasingly conservative agendas in the wake of global financial crisis and amidst the rise of radical-right populist politics, attention to the legacies of Latin America’s epistemological innovations and social movement action are especially warranted. This collection addresses three crosscutting themes: Working at the nexus of activism, policy, and health equity, this multidisciplinary collection offers new perspective on struggles for justice in twenty-first-century Latin America. The chapters in this book were originally published as a special issue of the journal,