This authoritative text takes a biopsychosocial approach to understanding the role of stress in alcohol use disorder, posttraumatic stress disorder, depression, cardiovascular disease, type 2 diabetes, cancer, and other chronic diseases. It presents cutting-edge knowledge about how stressors are conceptualized and measured; connections to disease processes; systemic racism as a significant, ongoing stressor for people of color; and factors that promote resilience. For each of the disorders discussed, proven and promising stress-targeted clinical interventions are reviewed. Student-friendly features include an end-of-book glossary and an extensive bibliography to facilitate in-depth study of selected topics of interest.