This publication brings together the work of experts applying different physical methods to problems of macromolecular dynamics - notably x-ray diffraction, NMR and other forms of spectroscopy, and macromolecular dynamics measurements and simulations. Emphasis was placed on correlating structural problems with mechanisms of biological function. The range of topics in this book represent the diversity of critical problems in biology, from protein structure determination and folding dynamics to the mechanisms of allostery in enzymes from RNA structure and function in viral disease to the triumph of the ribosome structure. The individual articles represent the state-of-the-art in each area covered and provide a guide to the original literature in this rapidly developing field.