E.B. White's classic children's story is brought to the screen in this fantasy, which combines computer-animated characters with a cast of live actors. Mrs. Little (Geena Davis), Mr. Little (Hugh Laurie), and their son George (Jonathan Lipnicki) live in a brownstone near New York's Central Park. The Littles have decided to adopt a younger brother for George, and while they're meeting the children at an orphanage, they are greeted by a mouse named Stuart (voice of Michael J. Fox), who can talk, walk upright, wear clothes, and do nearly anything a human child can do. The Littles are so taken with Stuart that they decide to adopt him, and soon the rest of the family is just as charmed by Stuart -- with the possible exception of Snowbell (voice of Nathan Lane), their house cat. The cast of humans includes Jennifer Tilly, Bruno Kirby, and Dabney Coleman; animal voices are contributed by Chazz Palminteri and Steve Zahn, Jim Doughan, and David Alan Grier.