This book constitutes the refereed proceedings of the 13th International Conference on Subject-Oriented Business Process Management, S-BPM ONE 2022, held in Karlsruhe, Germany, during June 29–July 1, 2022. The 7 full papers and 4 short papers included in this book were carefully reviewed and selected from 15 submissions. They were organized in topical sections as follows: technology; application; and short papers.