Collectively, the authors demonstrate that no particular combination has emerged as the most dominant, or even resilient, model of innovation. Several authors expand on our understanding of the triple helix model, with both academics and practitioners looking to the quadruple helix (encompassing business, academic, government, and civil society) as the new standard. Other authors address aspects of open innovation, co-creation, and user-centered design—all testaments to the rapidly shifting landscape. At the same time, many businesses, academics, and governments, not to mention non-profit organizations, foundations, and society at large, are active in conversations about how to pursue a more sustainable model of innovation. The pursuit of this holy grail of innovation is both facilitated and complicated by an ever-accelerating technological environment in which social networking and mobile tools are emerging as new dance arenas.