Contents: L. Banfi—A. Basso—R. Riva: Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups.- V.A. Chebanov—K. A. Gura—S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang—K. Khoury—A. Dömling: Piperazine Scaffolds by Multicomponent 3 Reactions: The Piperazine Space 4 in MCR Chemistry 5 Deep MCR Piperazine Space.- N. Elders—E. Ruijter—V.G. Nenajdenko—R.V.A. Orru: α-Acidic Isocyanides in Multicomponent Chemistry.- A. Cukalovic—J.-C.M.R. Monbaliu—C.V. Stevens: Microreactor Technology as an Efficient Tool for Multicomponent Reactions.- L.A. Wessjohann—C.R.B. Rhoden—D.G. Rivera—O. Eichler Vercillo: Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions.- M. del Mar Sanchez Duque—C. Allais—N. Isambert—T. Constantieux—J. Rodriguez: ß-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles