New or noteworthy coverage includes the following: • A chapter devoted to the legal and practical aspects of addiction in the occupational sphere, designed for clinicians who treat people with SUDs and/or develop workplace testing programs, employee assistance programs, and occupational drug/alcohol policies for these workers.• A chapter that surveys the growing literature supporting the use of mindfulness, exercise, and other "mind and body" practices (e.g., yoga, acupuncture, tai chi) as complements or alternatives to standard SUD treatment models.• A chapter devoted to hallucinogens, which clarifies their actions, psychoactive effects, historical uses, potential therapeutic benefits, and neural mechanisms, and both identifies their risks and seeks to dispel some of the misconceptions that have continued to surround them.• A suite of chapters devoted to cannabis, encompassing a review of its neurobiology and history, a survey of effective treatment approaches and harm-reduction strategies for cannabis use disorder, and a consideration of evolving public policy around cannabis use.• A trio of chapters devoted to nicotine and tobacco, encompassing a review of neurobiology, a survey of clinical assessment tools, a summary of the research base for effective treatments for tobacco use disorder, and a consideration of public health policy and interventions regarding tobacco use. Evidence-based, down to earth, and meticulously edited, the new Sixth Edition of The American Psychiatric Association Publishing Textbook of Substance Use Disorder Treatment is an essential resource for clinicians who treat SUDs in a variety of settings—from examining rooms to emergency departments, and from hospitals to recovery facilities.