During the 1910 appearance of Halley's comet, madman Szilveszter Matuska and his acolytes attempt to rip a hole in the fabric of reality to call forth Cthulhu. After an explosive confrontation, Albert Einstein and Howard Phillips Lovecraft follow Szilveszter through a rip in time back to 1879 and find themselves in the New Mexico territory. Taking advantage of the opportunity, Szilveszter coaxes assistance from Lizzie Borden, Thomas Edison, Nikola Tesla, and other infamous figures of the time to further him along toward his nefarious goals. Albert and Howard give chase across half the globe, enlisting aid from Billy the Kid, Calamity Jane, Annie Oakley, and Jules Verne.