Mayme Holloway knows how to keep secrets. Wounded outlaws often call on her medical skills and trust her silence. When Charley Floyd and his wife pay their old friends, Mayme and O.C. a visit, everything changes. Charley, aka Pretty Boy Floyd, is wanted for killing a lawman. His wounds require more help than Mayme can provide which forces her to break her silence and seek help from Dr. Joe Stern. While O.C., safely cuts hair at his barbershop, whistling hymns and telling jokes, Mayme and Dr. Stern venture out into the Cookson Hills to treat Pretty Boy Floyd. Over time, Joe and Mayme forge a strong bond as they care for other wounded men. They share dangerous secrets, dangerous lives, dangerous patients and a dangerous love.