For this volume, , we define health care management as the planning, direction, and coordination of health services and the management of health care professionals. Included chapters consider five grand challenges facing the health care sector: (1) caring for vulnerable populations; (2) maintaining the health care workforce; (3) translating innovation into practice; (4) sustaining organizations; and (5) navigating pandemics. Each challenge is discussed in its own section and addressed by two chapters that offer different perspectives and approaches to the challenge. Across chapters a variety of methodologies are used including ethnographic case studies, survey data analysis, interviews, literature review, and informed commentary. Together, the chapters in this volume synthesize current information in the field, direct future research efforts, and generate actionable insights for managers and policymakers.