Having made peace with his decision to die, Will is nonetheless convinced by a former patient to visit a healer, a mysterious and beautiful woman named Maya who claims she can help him, but only if he opens himself up completely to her and the harmony of the world around him. To find that harmony, she insists, Will must follow her to Mesoamerica, to the home of her people, to search for what she calls the Fifth Harmonic. Will agrees, but he secretly brings along what he calls a "Kevorkian Kit" to give him a quick end in case his rapidly spreading tumor gets the best of him. Maya too, has her secrets, and as Will unravels them, he begins to fear he might have made a terrible mistake.