With the planned withdrawal of U.S. military forces from Afghanistan, the U.S. has stated its intention of shifting attention away from the CASA Region in favor of a more isolationist foreign policy approach. This book provides an in-depth understanding of the implications for this shift related to regional diplomacy & politics, economic opportunities & rivalries, security considerations & interests, and the information environment. Amplifying the vital importance of success in the Central Region to U.S. prosperity and security, this volume advances dialogue in identifying key issues for stakeholders within and beyond the Central Region to gain a holistic perspective that better informs decision-making at various levels. This collection of work comes from scholars, strategic thinkers, and subject matter experts who participated in the Great Power Competition Conference hosted by the University of South Florida, in partnership with the National Defense University Near East South Asia Center for Strategic Strategies in January 2020.