On a warm summer night in New York City, the apocalypse begins. Within days, the deadly Medusa virus is sweeping the globe like a wildfire, pushing humanity to the brink of extinction. As civilization crumbles around him, survivor Adam Fisher will discover a flicker of hope that will send him on a quest through a ruined American landscape. He joins forces with Sarah Wells, a soldier harboring a tragic secret, and Freddie Briggs, an aging football star grieving the loss of his family. Together, the group will face challenges unlike any they have ever known, including the rise of a dangerous new enemy that will threaten the survivors' fragile existence.