The story of Doctor Jenner and smallpox is told by guests at a dinner party at an old English home, on the evening of the 180th anniversary of Doctor Jenner's death. To celebrate the occasion, the individuals review his life story, including his many discoveries and the trials and tribulations associated with smallpox vaccination being accepted as the way to prevent smallpox. Jenner eventually received universal acclaim. The guests at the dinner party, in the process of telling the story of Doctor Jenner, reveal a great deal about themselves.