Life appears ungraspable, yet its understanding lies at the heart of current preoccupations. In our attempt to understand life through its origins, the ambition of the present collection is to unravel the network of the origin of the various spheres of sense that carry it onwards. The primogenital matrix of generation (Tymieniecka), elaborated as the fulcrum of this collection, elucidates the main riddles of the scientific / philosophical controversies concerning the status of various spheres that seek to make sense of life.