It presents a comprehensive overview of AEE's current applications, including its extension into reading, speech, and mathematics, and writing research; modern automated feedback systems; critical issues in automated evaluation such as, psychometrics, fairness, bias, transparency, and validity; and the technological innovations that fuel current and future developments in this field. As AEE approaches a tipping point of global implementation, this Handbook stands as an essential resource, advocating for the conscientious adoption of AEE tools to enhance educational practices ethically. The Handbook will benefit readers by equipping them with the knowledge to thoughtfully integrate AEE, thereby enriching educational assessment, teaching, and learning worldwide. Aimed at researchers, educators, AEE developers, and policymakers, the Handbook is poised to chart the current landscape but also to stimulate scholarly discourse, define and inform best practices, and propel and guide future innovations.