San Diego firefighters Jimmy Dodd and Marty McLennan plan an overnight excursion to the seaport town of Ensenada, Mexico, for some good times. Jimmy's delinquent cousin Sonny Gabriel comes along for the ride. Suddenly, the trip spins horribly out of control when they accidentally kill the ruthless enforcer and brother of the head of a powerful drug cartel. The Americans race through a series of deadly gauntlets, vengeful cartel soldiers, corrupt policemen, and unforeseen detours as they make the run of their lives trying to reach the safety of the U.S. border. Their chance at redemption is slim. Their likelihood of survival is dismal. They're going to have to make one last run for home, or die trying in a no-man's-land between countries.