Subjects covered include documentary and archaeological evidence of cultural interaction, the collection of native artifacts and the role of museums in the interpretation of indigenous traditions, the cultural impact of Christian missions and the representation of indigenous cultures in writings addressed to European readers, the development of Latin American artistic traditions and the incorporation of motifs from European classical antiquity into modern popular culture, the contribution of Afro-descendants to the cultural mix of Latin America and the erasure of the Hispanic heritage from cultural perceptions of California since the nineteenth century. By offering accessible and well-illustrated accounts of a wide range of particular cases, the volume aims to stimulate thinking about historical and methodological issues, which can be exploited in a teaching context as well as in the furtherance of research projects in a comparative and transnational framework.