Global computing refers to computation over “global computers,” i.e., com- tational infrastructures available globally and able to provide uniform services with variable guarantees for communication, cooperation and mobility, resource usage, security policies and mechanisms, etc., with particular regard to explo- ing their universal scale and the programmability of their services. As the scope and computational power of such global infrastructures continue to grow, it - comes more and more important to develop methods, theories and techniques for trustworthy systems running on global computers. This book constitutes the thoroughly refereed proceedings of the fifth e- tion of the International Symposium on Trustworthy Global Computing (TGC 2010) that was held in Munich, Germany, February 24-26, 2010. The Symposium on Trustworthy Global Computing is an international annual venue dedicated to safe and reliable computation in global computers. It focuses on providing frameworks, tools, and prools for constructing well-behaved applications and on reasoning rigorouslyabout their behavior and properties. The related models of computation incorporate code and data mobility over distributed networks with highly dynamic topologies and heterogeneous devices.