This book traces several key themes underlying the core proposition that for a region to work, it has to link research and manufacturing activities — namely, innovation and production — in the same place. Among the topics discussed in this volume are the issues of how the location of research and development infrastructure produces a clear role of the state in innovation and production systems, and how policy emphasis on pre-production processes in the 1990s has obscured the financialization of intellectual property. Throughout the book, the author draws on examples from diverse industries, including the medical devices industry and the US photonics industry, in order to illustrate the different themes of working regions and the various institutional models operating in various countries and regions.